Generic name: sertaconazole topical (SER ta KON a zole) Brand name:Ertaczo,onabet Dosage forms: topical cream (2%) Drug class: Topical antifungals
What is sertaconazole topical?
Sertaconazole is an antifungal medicine that is used topically over the affected areas of the skin for the treatment of superficial fungal infections.
Sertaconazole topical is an antifungal medication that fights infections caused by fungus.
Sertaconazole topical (for the skin) is used to treat tinea pedis (athlete's foot) in adults and children who are at least 12 years old.
Sertaconazole topical may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use sertaconazole topical if you are allergic to it.
It is not known whether sertaconazole topical will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether sertaconazole topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not use sertaconazole topical on anyone under 12 years old without medical advice.
Uses:
Tinea pedis:
Topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
Off Label Use of Sertaconazole in Adults:
Cutaneous candidiasis;
Seborrheic dermatitis;
Tinea versicolor
Sertaconazole Dose in the treatment of Tinea pedis:
Apply topically between toes and to surrounding healthy skin two times a day for 4 weeks
Sertaconazole Dose in the treatment of Cutaneous candidiasis (off-label):
Topical: Apply to the affected area(s) two times a day for four weeks.
Dose in the treatment of Seborrheic dermatitis (off-label):
Topical: Apply to the affected area(s) two times a day for 4 weeks.
Sertaconazole Dose in the treatment of Tinea versicolor (off-label):
Apply topically to the affected area(s) two times a day for four weeks.
Sertaconazole dose in the treatment of Diaper dermatitis caused by candida: Limited data available:
Infants and Children 2 to 24 months:
Apply topically twice a day for 2 weeks.
Sertaconazole dose in the treatment of Tinea corporis:
Children ≥2 years and Adolescents:
Apply topically once a day for two weeks;
Sertaconazole dose in the treatment of Tinea pedis:
Children ≥12 years and Adolescents:
Apply topically between toes and to the surrounding healthy skin two times a day for 4 weeks.
Pregnancy Risk Factor C
In animal reproduction studies, adverse events following oral administration were not observed.
Use during breastfeeding:
It is unknown if the drug is found in breast milk.
It is recommended that lactating mothers be cautious when using it.
Dose in Kidney Disease:
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to minimal systemic absorption.
Dose in Liver disease:
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to minimal systemic absorption.
Side Effects of Sertaconazole:
Dermatologic:
Burning sensation of skin
Contact dermatitis
Skin tenderness
Xeroderma
Contraindications to Sertaconazole:
The manufacturer’s labeling does not list any contraindications.
Warnings and precautions
Irritation
If irritation is observed at the application site or hypersensitivity reactions occur, the treatment should be stopped immediately.
Monitoring parameters:
The patient’s condition should be reassessed after two weeks if no or minimal improvement is noted.
How to administer Sertaconazole?
It is applied over the affected area of the skin two times a day. The affected area should be cleaned and dried before applying the medicine.
Mechanism of action of Sertaconazole:
It blocks the CYP450-dependent synthesis ergosterol, resulting in the death of the fungi by altering the cell wall permeability.
Absorption:
After topical application, absorption is minimal.The serum concentration of the drug is below the limit for quantitation (2.5ng/mL).
International Brand Names of Sertaconazole:
Ertaczo
Dermofix
Dermofix Gyno Ovule
Fixitazol
Fuganol
Gyno-Zalain
Konzert
Monazol
Onabet
Sertacream
Zalain
Zalain Cream
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