Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
Guaifenesin is used to reduce chest congestion caused by the common cold, infections, or allergies.
Guaifenesin is used to loosen secretions and phlegm (mucus) so as to make it easy for the patient to expectorate and clear the airways and the lungs
Warnings
You should not use this medicine if you are allergic to guaifenesin.
Use this medicine exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.
Guaifenesin is commonly found as part of over-the-counter combination medications for cold and cough. Read labels or ask a doctor or pharmacist before using any other cold, or cough medicine when taking guaifenesin.
Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Before taking this medicine
Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, such as liver disease, kidney disease, or phenylketonuria (PKU).
It is not known whether guaifenesin will harm an unborn baby. Ask a doctor before using this medicine if you are pregnant.
It is not known whether guaifenesin passes into breast milk or if it could harm a nursing baby. Ask a doctor before using this medicine if you are breast-feeding a baby.
Do not give this medicine to a child without medical advice.
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Guaifenesin Uses:
Cough (as an expectorant):
It is used to help thin bronchial secretions and phlegm (mucus) so as to make it easy for the patient to expectorate the secretions. It may partly act as an antitussive as well.
Guaifenesin Dose in the treatment of Cough (as an expectorant):
Granules:
200 to 400 mg orally every four hours or as needed to a maximum dose of 2,400 mg per day.
Extended-release tablets:
600 mg to 1,200 mg orally twice a day as needed to a maximum dose of 2,400 mg per day.
Immediate-release tablet:
200 to 400 mg orally every four hours or as needed to a maximum dose of 2,400 mg per day.
Liquid:
200 to 400 mg orally every four hours as needed to a maximum dose of 2,400 mg per day.
Note:
The American Association of Pediatricians warns and recommends against the use of OTC cough syrups in infants and children younger than 2 years of age. Because of the serious and life-threatening side effects (and rarely death), the AAP also recommends using it with caution in children older than 2 years of age.
Guaifenesin Dose as an expectorant:
Liquid:
Children 2 years to <4 years:
50 to 100 mg orally every four hours as required.
Avoid exceeding six doses per day.
Children 4 years to <6 years:
50 to 100 mg orally every four hours as needed.
Avoid exceeding 6 doses per day.
Children 6 years to <12 years:
100 to 200 mg orally every four hours as needed.
Avoid exceeding six doses per day.
Children ≥12 years and Adolescents:
200 to 400 mg orally every four hours as needed.
Avoid exceeding 6 doses per day.
Granules:
Children 4 years to <6 years:
100 mg orally every four hours as needed.
Avoid exceeding six doses per day.
Children 6 years to <12 years:
100 to 200 mg orally every four hours as needed.
Avoid exceeding 6 doses per day.
Children ≥12 years and Adolescents:
200 to 400 mg orally every four hours as needed.
Avoid exceeding 6 doses per day.
Immediate-release tablet:
Children 6 years to <12 years:
200 mg orally every 4 hours as needed.
Avoid exceeding six doses per day.
Children ≥12 years and Adolescents:
400 mg orally every four hours as needed.
Avoid exceeding 6 doses per day.
Extended-release tablet:
Children ≥12 years and Adolescents:
600 mg to 1,200 mg orally twice daily as needed.
Avoid exceeding 2 doses or 2,400 mg per day.
Pregnancy Category: B
It is acceptable to use in normal doses as an OTC drug for cough or as an expectorant during pregnancy.
Avoid alcohol-containing products during pregnancy.Experts recommend that alcohol be avoided in severe cases, unless there are enough symptoms to cause discomfort for the mother.
Use of Guaifenesin during breastfeeding
It is not known whether it can be used in lactating mothers.Nursing women should avoid products containing alcohol.
Dose in Kidney disease:
There are no dosage adjustments provided in manufacturer’s labeling.
Dose in Liver disease:
There are no dosage adjustments provided in manufacturer’s labeling.
Side effects of Guaifenesin:
Central Nervous System:
Dizziness
Drowsiness
Headache
Dermatologic:
Skin Rash
Endocrine & Metabolic:
Hypouricemia
Gastrointestinal:
Nausea
Stomach Pain
Vomiting
Contraindications to Guaifenesin:
OTC labeling: Avoid the use of extended-release tablets in children 12 years of age or younger.
Monitoring Parameters:
None mentioned. Monitor for evidence of chest infection. Patients with underlying heart disease and chronic lung disease should seek expert opinion especially if there are concomitant symptoms like shortness of breath and fever.
How to administer Guaifenesin?
Oral:
It is administered orally following meals with plenty of liquid or water.
Extended-release tablet:
The extended-release tablets should be administered following meals without breaking, chewing, or crushing the tablets.
Granules:
Empty the contents of the packet onto the tongue and swallow without chewing the granules to avoid distaste.
Mechanism of action of Guaifenesin:
It is used as a cough expectorant because it lowers the viscosity (phlegm) and increases the hydration of your respiratory tract.
It can also be used as an antitussive to suppress the cough reflex in patients with upper respiratory tract infection (but not healthy subjects).It is unknown what the exact mechanism of antitussive action is.It could have antitussive central effects, or suppress cough by increasing the volume of sputum. This acts as a barrier against tussive stimuli by covering hypersensitive respiratory epithelium.
Absorption:
Well absorbed
Excretion:
Urine
International Brand Names of Guaifenesin:
Altarussin
Bidex
Buckleys Chest Congestion
Diabetic Siltussin DAS-Na
Diabetic Tussin
Fenesin IR
Geri-Tussin
GoodSense Mucus Relief
Iophen-NR
Liquibid
Liquituss GG
Mucinex Chest Congestion Child
Mucinex For Kids
Mucinex Maximum Strength
Mucinex
Mucosa
Mucus Relief Childrens
Mucus Relief ER
Mucus Relief
Mucus-ER
Organ-I NR
Pharbinex
Q-Tussin
Refenesen 400
Refenesen
Robafen Mucus/Chest Congestion
Robafen
Robitussin Mucus+Chest Congest
Scot-Tussin Expectorant
Siltussin DAS
Siltussin SA
Tussin Mucus & Chest Congest
Tussin
Xpect
Benylin Childrens Chesty Cough
Borstol Linctus Orange Flavour
Borstol Linctus Peppermint Flavour
Breacol
Bronchosedal Mucus
Broncofenil
Chamberlain`s Cough Remedy
Codimal
Cofen
Coldrex Broncho
Deflenol
Desbly
Dextricyl
Excaugh
Expelinct
Fagusan N Losung
Fenatussin
Flemonex
Formulaexpec
Frispec
Glyteol
Guaiatussin
Guajacuran
Guajazyl
Guaphan
Gwajafen
Iniston
Kosorex
Kosorex Strong
Lemsip Chesty Cough
Mucinex
Numark Chesty Cough
Pectal
Pectal Expectorant
Pharmachem
Probat
Relaxil-G
Resyl
Robitessin
Robitussin
Robitussin Chesty Cough
Robitussin EX
Robitussin Expectorant
Robitussin Plain
Sipla
Suprekof
Tintus
Transpulmin G
Vicks expectorant adulte
Vicks Mucus Cough
Vicks Vaposyrup
Wick Formula 44 Plus L
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